CRM may refer to:
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Sales and marketing [link]
- Customer relationship management, processes implemented by a company to handle its contact with its customers
- cause-related marketing, a type of marketing
- Courtesy reply mail, a type of business mail
Companies and institutions [link]
- Centre de Recherches Mathématiques, a Canadian mathematical research institute
- Comas Racing Management, a driver management firm of Érik Comas
- Commander Mexicana's ICAO code
Resource management [link]
- Crew Resource Management or Cockpit Resource Management, an aviation training program
- Cultural resources management, the practice of managing cultural resources
Other [link]
- Cis-regulatory module, a region of DNA,
- Cardiac rhythm management
- Caloric restriction mimetic, a substance that mimics the caloric restriction anti-ageing effect
- Canadian Risk Mangement, a professional designation in risk management
- Certified reference materials, ‘controls’ or standards used to check the quality and traceability of products
- Certified Resident Manager, a professional designation in property management
- Certified Risk Manager, a professional designation
- Certified Records Manager, a professional designation
- CIDOC Conceptual Reference Model, an international standard for the exchange of cultural heritage information
- Concrete Rubble Masonry, a type of wall construction
- Civil Rights Movement, an anti-racism campaign
- Chittaranjan Mitra, or C.R.Mitra, an Indian Scientist
See also [link]
- CRM 114 (device), a device in Stanley Kubrick's film Dr. Strangelove
- CRM114 (program), a statistical classifier and pattern matching language commonly used to filter spam
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https://wn.com/CRM
CRM197
CRM197 is a non-toxic mutant of diphtheria toxin, currently used as a carrier protein for polysaccharides and haptens to make them immunogenic.
Description
CRM197 is a genetically detoxified form of diphtheria toxin. A single mutation at position 52, substituting glutamic acid for glycine, causes the ADP-ribosyltransferase activity of the native toxin to be lost. The structural basis for the lack of CRM197 toxicity has recently been elucidated. CRM197 is widely used as a carrier protein for conjugate vaccines. An advantage of CRM197 over toxoided proteins is that, because it is genetically detoxified, it retains its full complement of lysine amines for conjugation. There is also evidence suggesting that, compared with tetanus toxoid, there is less carrier-induced suppression of the immune response, especially when there are many individual polysaccharides linked to the same carrier protein. A summary of the uses and properties of CRM197 has been published. CRM197, like diphtheria toxin, is a single polypeptide chain of 535 amino acids (58.4 kD) consisting of two subunits (linked by disulfide bridges).
